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About Roche SMA Trials

Roche is developing two investigational medicines for SMA, Olesoxime and RG7916.

RG7916 is developed in collaboration with the SMA Foundation and PTC Therapeutics. RG7916 and Olesoxime are given by mouth or feeding tube.

In our FIREFISH, SUNFISH and JEWELFISH trials we aim to learn if RG7916 (also known as RO7034067) is safe and effective.

In our OLEOS clinical trial we aim to learn about long term safety and efficacy of Olesoxime.

 

Our clinical trial for Type 1 SMA is called FIREFISH.

This is a clinical trial in babies aged between 1 to 7 months.

Find out more about FIREFISH here.

Our clinical trials for SMA Type 2 and Type 3 are called SUNFISH, JEWELFISH and OLEOS.

The SUNFISH trial examines RG7916 in people aged 2 – 25 years with Type 2/3 SMA.

Find out more about SUNFISH here.

The JEWELFISH trial examines RG7916 in people aged 12 – 60 years with Type 2/3 SMA. The clinical trial is for people who have previously participated in a trial with SMN2 targeting therapies.

Find out more about JEWELFISH here.

The OLEOS trial assesses Olesoxime in children and adults with Type 2 or 3 SMA. This clinical trial is for people who have previously participated in a trial with Olesoxime.

Find out more about OLEOS here.

Visit ClinicalTrials.gov for more information about FIREFISH, SUNFISH, JEWELFISH OR OLEOS.